We understand that exploring research questions using optimized and validated methods are vital step in the drug development process. We will work with you to determine the right laboratory environment based on the requirements of your study. With customizable solutions and our network of qualified specialty laboratories, we help you identify biomarkers and profile the molecular landscape most relevant to your compound and target indication. We ensure sample quality and integrity from collection to analysis.
We have combined world-renowned GI expertise and cutting-edge translational technologies to accelerate your drug development.
Identification of biomarkers is the defining component of Precision Medicine and is key to improving the way we diagnose and treat patients. Discovering predictive or pharmacodynamic/monitoring biomarkers will enable a better understanding of clinical effects and eventually allow for targeting a specific patient population most suitable to respond to the therapy.
We have combined world-renowned GI expertise and cutting-edge translational technologies to accelerate your drug development program. The potential for biomarker discovery is easier than ever due to advances in technology and sample throughput capabilities. At Alimentiv, the delivery of high-quality data is our top priority, empowering you to make informed decisions faster.
Our Precision Medicine team will work with you to determine the right technology and the right laboratory environment based on the requirements of your project. With customizable solutions, we will help you identify biomarkers or profile the molecular landscape to further determine your compound’s mechanism of action. Our network of specialized laboratories provides high-quality services to meet the specific needs of your research project or clinical study, all within an accredited facility (i.e. GcLP, CAP, CLIA, and/or ISO 15189 compliant).
We understand that exploring research questions and optimizing and validating methods are vital steps in the drug development process. Our experienced Precision Medicine specialists and laboratories are your perfect research partners to deliver:
Histology imaging is a core service at Alimentiv. The collection and histological assessment of biopsies in the majority of GI clinical trials provides the ideal opportunity to determine the effect of your compound at the site of action. Sample collection and analysis are critical steps. Our Precision Medicine team in collaboration with our Pathology specialists have the experience and expertise to ensure that you obtain valuable, high-quality data. Immunohistochemistry offers the power and flexibility to identify biomarkers, determine target engagement, monitor immune cell subsets, and assess mechanism of action. Coupled with digital image analysis, where optimized algorithms can provide automated quantitation in regions of interest or select tissue types, we can help you gain additional insights.
Our Precision Medicine team offers expert recommendations on:
Flow cytometry is a powerful tool for elucidating the mechanism of action of anti-inflammatory drugs in immune-mediated gastrointestinal diseases. Measuring changes in immune cell populations and relevant cellular targets following therapy may accelerate drug development by providing insights into target engagement and mechanism of action. Our specialty labs have deep expertise in flow cytometry and offer multiplexed solutions for analyzing blood and tissue samples. At Alimentiv, we know that understanding the changes occurring at the site of action is critical. To meet this need, we have developed and optimized a cryopreservation method for intestinal mucosal tissue samples, enabling batched analysis.
Alimentiv Precision Medicine offers end-to-end flow cytometry support:
We offer flexible and customizable solutions to enable high-quality data-driven insights for protein biomarker discovery. Identification of predictive or pharmacodynamic/monitoring biomarkers can be efficiently achieved through targeted or multiplexed protein assays with limited sample volumes. We can help you get more out of your clinical samples by offering high-throughput, state-of-the-art platforms for measuring select proteins or discovering immune signatures. Our team of GI-expert scientists will help you plan your biomarker strategy, perform sample analysis and correlate data with clinical endpoints to maximize discovery.
Alimentiv offers end-to-end support, simplifying biomarker discovery by offering:
We offer a full range of customized services, from global-level DNA and RNA analysis using Next-Generation Sequencing (Genomics and Transcriptomics analysis) to targeted gene analysis using quantitative reverse transcription PCR. Our state-of-the-art platforms coupled with our bioinformatics expertise make evaluating individual genomic characteristics and drug-induced gene expression changes comprehensive and efficient. Our strength is based on a deep knowledge of gene expression changes associated with GI diseases and therapeutics, experimental design, as well as extensive experience in the development and implementation of many different transcriptomic methodologies. We can provide input at the early planning phase of an experiment, as well as perform transcriptomic services at any stage of a project, including analysis and interpretation of results, customized to each sponsor’s specific needs.
Our services include:
We offer cutting-edge microbiome genomics platforms, including metagenomic whole genome sequencing, to evaluate the role of the gut microbiome and gut dysbiosis on your drug. Our team can support your research questions and seamlessly guide you through your clinical study by providing end-to-end expertise on study design, sample collection, sequencing analysis and bioinformatics.
To apply microbiome research to your clinical study we offer:
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Join us at UEG Week to explore Alimentiv’s groundbreaking research, which is showcased across four posters.
When: October 12-15, 2024 in Vienna, Austria
Where: Messe Wien Exhibition Congress Center
Booth #57