Publications
Early Combined Immunosuppression Reduces Complications in Long-standing Crohn’s Disease: A Post Hoc Analysis of REACT
Citation
Hanzel J, Ma C, Zou G, Singh S, Dulai PS, Feagan BG, D'Haens GR, Sandborn WJ, Jairath V. Early Combined Immunosuppression Reduces Complications in Long-standing Crohn's Disease: A Post Hoc Analysis of REACT. Clin Gastroenterol Hepatol. 2022 Jan;20(1):236-238. DOI: 10.1016/j.cgh.2020.12.019. Epub 2020 Dec 18. PMID: 33346141.
Abstract
Crohn’s disease (CD) can lead to bowel damage, stricturing, and obstruction thereby resulting in surgery and hospitalization. The Randomized Evaluation of an Algorithm for Crohn’s Treatment (REACT) trial showed that early combined immunosuppression (ECI) with symptom-based treatment escalation for 24 months resulted in a lower risk of surgery, hospitalization, or CD-related complications compared with conventional management (CM).