R&D Leadership

our people

MR&D_Header_900x390_R&D Leadership

Our Medical R&D leaders have individually and collectively made academic contributions to clinical, biostatistical and translational research that are driving the evolution of both clinical trial design and the treatment of chronic inflammatory diseases. We are tackling the most difficult unmet research and medical needs and providing solutions to improve human health. Client access to and collaboration with these academic experts differentiates Alimentiv from traditional Contract Research Organizations.

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R&D Leadership

Guangyong (GY) Zou

PhD - Biostatistician Director

Guangyong (GY) Zou

PhD - Biostatistician Director

After completing PhDs in Biostatistics and Plant Science from the University of Connecticut, Dr. Zou joined Alimentiv in September 2002. He is currently Professor of Epidemiology and Biostatistics at Western University.

Background

Dr. Zou oversees statistical support for Medical R&D programs, as well as Alimentiv IBD clinical research.

He has over 20 years of experience designing and analyzing clinical trials, including cluster randomization trials. His research has primarily focused on development and evaluation of statistical methods for medical research. At Alimentiv, he’s also researching endpoint development and validation, larger-scale effectiveness research and strategy trials.

He has published over 150 peer-reviewed articles, many of which have impacted medical and epidemiologic research. A single-authored 2004 article on regression models for estimating risk ratios has already received close to 3,000 citations.

Achievements

Dr. Zou wrote a 2004 paper on estimation of risk ratios that’s been cited close to 5,000 times, and a 2012 paper that Alimentiv uses to design reliability studies.

Ethos

“Results are only as good as the statistical methodology used to obtain them. My goal is to continuously create good statistical methodology for medical research.”


Vipul Jairath

Vice President for Medical Research and Development

Vipul Jairath

Vice President for Medical Research and Development

Dr. Jairath oversees the global Medical R&D initiatives and services. In conjunction with the executive team and senior medical advisors, he assumes overall responsibility for research strategy, as well as performance of the organization’s Medical R&D services including medical operations, medical imaging, precision medicine, medical writing, medical monitoring, medical/biostatistics advisory collaborations and IBD fellowships. He also provides medical oversight for the design of clinical trials, protocol development and imaging R&D endpoints. Dr. Jairath was previously Director of Academic Research and Development (2016-19).

Background

Dr. Jairath obtained his BSc (Pharmacology) and Medical Degree from the University of Leeds (UK), DPhil (PhD) in Clinical Medicine from the University of Oxford and post-graduate diploma in Clinical Trials from the London School of Hygiene and Tropical Medicine. He is Professor of Medicine at the Schulich School of Medicine and Dentistry, and holder of the John and Susan McDonald Endowed Chair in Inflammatory Bowel Disease (IBD) at Western University.

His specialist clinical training in Gastroenterology was completed in London and Oxford, and he holds specialist certification in both Ontario and the UK. Prior to moving to Western in 2016, he was a National Institute for Health Research Clinical Trials Fellow at the Oxford Clinical Trials Research Unit and Consultant Gastroenterologist at Oxford University Hospitals.

He is a practising gastroenterologist and specialist in IBD, and his research interests in clinical therapeutics for IBD include design of clinical trials, development and validation of outcome measures for use in clinical trials, patient reported outcome measures and prediction modelling for response to therapy.

Achievements

Dr. Jairath has driven the development and validation of several novel indices for use in IBD clinical trials, like the UC-100 and the novel patient reported outcome measures, Symptom and Impacts Questionnaire for Ulcerative Colitis and Symptom and Impacts Questionnaire for Crohn’s Disease. In addition, he was instrumental to the delivery of the REACT2 trial and to the design of the VERDICT trial, both of which are important clinical practice questions for patients with Crohn’s disease and ulcerative colitis, respectively.

Ethos

“We are what we repeatedly do. Excellence, then, is not an act, but a habit.” — Aristotle


Christopher Ma

MD, Medical Director

Christopher Ma

MD, Medical Director

Dr. Ma supports medical R&D projects.

Background

Dr. Ma obtained his MD from the University of Calgary in 2012. He completed his Internal Medicine residency at the University of Alberta, adult gastroenterology training at the University of Calgary and advanced IBD fellowships at the University of Calgary and Western University. In 2018, he completed a one-year Robarts IBD Clinical Trials Fellowship and in 2019 he earned an  MPH in Epidemiology from Harvard University.

Ethos

“Teamwork is everything.”



Guangyong (GY) Zou

PhD - Biostatistician Director

After completing PhDs in Biostatistics and Plant Science from the University of Connecticut, Dr. Zou joined Alimentiv in September 2002. He is currently Professor of Epidemiology and Biostatistics at Western University.

Background

Dr. Zou oversees statistical support for Medical R&D programs, as well as Alimentiv IBD clinical research.

He has over 20 years of experience designing and analyzing clinical trials, including cluster randomization trials. His research has primarily focused on development and evaluation of statistical methods for medical research. At Alimentiv, he’s also researching endpoint development and validation, larger-scale effectiveness research and strategy trials.

He has published over 150 peer-reviewed articles, many of which have impacted medical and epidemiologic research. A single-authored 2004 article on regression models for estimating risk ratios has already received close to 3,000 citations.

Achievements

Dr. Zou wrote a 2004 paper on estimation of risk ratios that’s been cited close to 5,000 times, and a 2012 paper that Alimentiv uses to design reliability studies.

Ethos

“Results are only as good as the statistical methodology used to obtain them. My goal is to continuously create good statistical methodology for medical research.”



Vipul Jairath

Vice President for Medical Research and Development

Dr. Jairath oversees the global Medical R&D initiatives and services. In conjunction with the executive team and senior medical advisors, he assumes overall responsibility for research strategy, as well as performance of the organization’s Medical R&D services including medical operations, medical imaging, precision medicine, medical writing, medical monitoring, medical/biostatistics advisory collaborations and IBD fellowships. He also provides medical oversight for the design of clinical trials, protocol development and imaging R&D endpoints. Dr. Jairath was previously Director of Academic Research and Development (2016-19).

Background

Dr. Jairath obtained his BSc (Pharmacology) and Medical Degree from the University of Leeds (UK), DPhil (PhD) in Clinical Medicine from the University of Oxford and post-graduate diploma in Clinical Trials from the London School of Hygiene and Tropical Medicine. He is Professor of Medicine at the Schulich School of Medicine and Dentistry, and holder of the John and Susan McDonald Endowed Chair in Inflammatory Bowel Disease (IBD) at Western University.

His specialist clinical training in Gastroenterology was completed in London and Oxford, and he holds specialist certification in both Ontario and the UK. Prior to moving to Western in 2016, he was a National Institute for Health Research Clinical Trials Fellow at the Oxford Clinical Trials Research Unit and Consultant Gastroenterologist at Oxford University Hospitals.

He is a practising gastroenterologist and specialist in IBD, and his research interests in clinical therapeutics for IBD include design of clinical trials, development and validation of outcome measures for use in clinical trials, patient reported outcome measures and prediction modelling for response to therapy.

Achievements

Dr. Jairath has driven the development and validation of several novel indices for use in IBD clinical trials, like the UC-100 and the novel patient reported outcome measures, Symptom and Impacts Questionnaire for Ulcerative Colitis and Symptom and Impacts Questionnaire for Crohn’s Disease. In addition, he was instrumental to the delivery of the REACT2 trial and to the design of the VERDICT trial, both of which are important clinical practice questions for patients with Crohn’s disease and ulcerative colitis, respectively.

Ethos

“We are what we repeatedly do. Excellence, then, is not an act, but a habit.” — Aristotle



Christopher Ma

MD, Medical Director

Dr. Ma supports medical R&D projects.

Background

Dr. Ma obtained his MD from the University of Calgary in 2012. He completed his Internal Medicine residency at the University of Alberta, adult gastroenterology training at the University of Calgary and advanced IBD fellowships at the University of Calgary and Western University. In 2018, he completed a one-year Robarts IBD Clinical Trials Fellowship and in 2019 he earned an  MPH in Epidemiology from Harvard University.

Ethos

“Teamwork is everything.”


Gabriela Radulescu

MD, Director, Medical Operations

Gabriela Radulescu

MD, Director, Medical Operations

Gabriela provides medical leadership for sponsor clinical trials, operational oversight for research and development projects, and medical input to the business development teams.

Background

Gabriela obtained her medical degree at the University of Medicine and Pharmacy Iuliu Hatieganu in Cluj – Napoca, Romania. Since then, she has acquired more than 20 years of experience working in the pharmaceutical industry in Canada in various leadership roles and across multiple functions including medical affairs, drug safety and pharmacovigilance, clinical research and real world evidence, and patient support programs. Prior to joining Alimentiv, Gabriela led a team of scientific professionals as a Medical Affairs Director in IBD.

Achievements

Since joining Alimentiv, through her multidisciplinary experience, Gabriela has been able to bring significant contributions to the development and implementation of organizational strategies and best practices. Her focus on the medical research and development area ensures a continued adherence to delivering high-quality research and science, superior customer service and people development.

Ethos

“I approach my role with the conviction that what we do matters for patients and physicians, and through our work we advance our mission to support human health. I believe it is important that every member of the Alimentiv team is authentic and brings their full contribution to the success of the organization.”


Niels Vande Casteele

PharmD, PhD Director, Precision Medicine

Niels Vande Casteele

PharmD, PhD Director, Precision Medicine

Dr. Vande Casteele established the precision medicine group where he oversees the development, validation and operationalization of clinical pharmacology & translational medicine research tools to ascertain efficient drug development.

Background

Dr. Vande Casteele holds a Bachelor of Pharmaceutical Sciences and Masters in Drug Design and Development from the University of Leuven, Belgium. He performed research in the fields of molecular biology at the Institute of Medical Sciences, University of Aberdeen, Scotland, and in immunology at Sanquin, University of Amsterdam, the Netherlands. He obtained his Ph.D. in Pharmaceutical Sciences based on his research dissertation entitled “Optimizing anti-TNF therapy in inflammatory bowel disease patients, a step towards personalized dosing” at the University of Leuven, Belgium.

Dr. Vande Casteele currently holds an appointment as Assistant Professor of Medicine at the University of California San Diego, where he teaches a course on Biologics and Biosimilars Drug Development. His main research efforts focus on clinical pharmacology and translational medicine of small and large molecules used in the treatment of chronic inflammatory diseases, with an emphasis on characterizing pharmacokinetics and pharmacodynamics in relation to treatment outcomes in clinical practice and drug development.

Achievements

Dr. Vande Casteele has published over 100 peer reviewed research articles and book chapters; has given over 30 invited lectures; and has received awards for his research contributions from distinguished professional organizations such as the European Crohn’s and Colitis Organization (ECCO), the American Gastroenterological Association (AGA), the Crohn’s and Colitis Foundation (CCF) and United European Gastroenterology (UEG) association.

Ethos

“Just like you have to climb the mountain in order to see the view, doing scientific research requires inquisitiveness, adaptiveness and a team approach to overcome hurdles in order to reach the objective.”



Gabriela Radulescu

MD, Director, Medical Operations

Gabriela provides medical leadership for sponsor clinical trials, operational oversight for research and development projects, and medical input to the business development teams.

Background

Gabriela obtained her medical degree at the University of Medicine and Pharmacy Iuliu Hatieganu in Cluj – Napoca, Romania. Since then, she has acquired more than 20 years of experience working in the pharmaceutical industry in Canada in various leadership roles and across multiple functions including medical affairs, drug safety and pharmacovigilance, clinical research and real world evidence, and patient support programs. Prior to joining Alimentiv, Gabriela led a team of scientific professionals as a Medical Affairs Director in IBD.

Achievements

Since joining Alimentiv, through her multidisciplinary experience, Gabriela has been able to bring significant contributions to the development and implementation of organizational strategies and best practices. Her focus on the medical research and development area ensures a continued adherence to delivering high-quality research and science, superior customer service and people development.

Ethos

“I approach my role with the conviction that what we do matters for patients and physicians, and through our work we advance our mission to support human health. I believe it is important that every member of the Alimentiv team is authentic and brings their full contribution to the success of the organization.”



Niels Vande Casteele

PharmD, PhD Director, Precision Medicine

Dr. Vande Casteele established the precision medicine group where he oversees the development, validation and operationalization of clinical pharmacology & translational medicine research tools to ascertain efficient drug development.

Background

Dr. Vande Casteele holds a Bachelor of Pharmaceutical Sciences and Masters in Drug Design and Development from the University of Leuven, Belgium. He performed research in the fields of molecular biology at the Institute of Medical Sciences, University of Aberdeen, Scotland, and in immunology at Sanquin, University of Amsterdam, the Netherlands. He obtained his Ph.D. in Pharmaceutical Sciences based on his research dissertation entitled “Optimizing anti-TNF therapy in inflammatory bowel disease patients, a step towards personalized dosing” at the University of Leuven, Belgium.

Dr. Vande Casteele currently holds an appointment as Assistant Professor of Medicine at the University of California San Diego, where he teaches a course on Biologics and Biosimilars Drug Development. His main research efforts focus on clinical pharmacology and translational medicine of small and large molecules used in the treatment of chronic inflammatory diseases, with an emphasis on characterizing pharmacokinetics and pharmacodynamics in relation to treatment outcomes in clinical practice and drug development.

Achievements

Dr. Vande Casteele has published over 100 peer reviewed research articles and book chapters; has given over 30 invited lectures; and has received awards for his research contributions from distinguished professional organizations such as the European Crohn’s and Colitis Organization (ECCO), the American Gastroenterological Association (AGA), the Crohn’s and Colitis Foundation (CCF) and United European Gastroenterology (UEG) association.

Ethos

“Just like you have to climb the mountain in order to see the view, doing scientific research requires inquisitiveness, adaptiveness and a team approach to overcome hurdles in order to reach the objective.”